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Research shows that at some point during the course of any illness, physical as well as mental, most people go off their medicines. There are many reasons a person may stop taking their medication, including: 1) The drug has stopped the symptoms. 2) They don't want to believe that they are chronically ill and need medicine. 3) The medicine has powerful, negative side effects such as sedation, agitation, constipation, weight-gain, and worse. 4) They can't afford a particular medication.